Projects

Advanced in silico cardiovascular modeling in hemorrhagic shock

This project aims to simulate heart activity and heart tissue behavior during severe hemorrhagic shock, with an emphasis on speedy testing. We’ll be using entirely computer-based models for this. The initial outcomes of this project will be two linked models running on a supercomputer: one model will represent the overall heart and blood vessel changes during hemorrhagic shock, and the other will represent heart tissue, for example, a group of cell models in tissue reacting to the body-wide stress caused by these conditions

IdentiPhy

Recent breakthroughs in hiPSC research have led to the development of ‘heart-on-chip’ models, offering potential for transformative drug development, but the integration of these models into pipelines remains a challenge; the IdentiPhy project aims to address this by creating technology that enhances compound safety risk prediction using optical measurements and computational analysis, with the goal of improving the efficiency and reducing costs and time in bringing safe drugs to market.

SimcardioTest

Simulation of Cardiac Devices and Drugs for In-Silico Testing and Certification (SimCardioTest)